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What is intra-vaginal drug delivery system?

Bliss GVS Pharma Limited / Uncategorized  / What is intra-vaginal drug delivery system?

What is intra-vaginal drug delivery system?

What are different types of intra-vaginal drug delivery system?

  • Vaginal rings.
  • Vaginal gel, creams and ointments.
  • Vaginal gel, creams and ointments.
  • Pessaries, tablets and suppositories.
  • Bio-adhesive, micro-particulate drug delivery devices or systems.
  • Others like foams, capsules, films, tampons, sponge and diaphragms.

Advantages of intra – vaginal drug delivery system:

  • In case of nausea and vomiting, the act of taking medication orally may induce emesis hence the drug is vomited out before it is absorbed.
  • Irritation to the stomach and small intestine associated with certain drugs can be avoided.
  • Hepatic first pass elimination of high clearance drugs may be avoided partially.
  • Contact with digestive fluid is avoided, thereby preventing enzymatic degradation of some drugs.
  • The vaginal bio-availability of smaller drug molecules is good.
  • The bio-availability of larger drug molecules can be improved by means of absorption enhancer or other approach.
  • Self medication is possible.
  • Convenient access.
  • Prolonged retention of formulation.
  • A great permeation area.
  • High vasculature.

Limitations of intra – vaginal drug delivery system:

    • Some of the drugs are sensitive at the vaginal pH.
    • Local irritation of some drugs.
    • Influence of sexual intercourse.
    • Gender specificity.
    • Personal hygiene.
    • Sometimes leakage of drugs from vagina and wetting of undergarments.

By Dr. Vibha Kamath

 

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