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Advantages and Disadvantages of Suppositories/Pessaries or rectal/vaginal route of drug administration…

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Advantages and Disadvantages of Suppositories/Pessaries or rectal/vaginal route of drug administration…

ADVANTAGES OF SUPPOSITORIES

    • Over Oral Drug Administration:
      • Avoid first pass metabolism
      • Introduce drugs into the body
      • Does not cause nausea and vomiting due to gastric irritation in case of oral therapy
      • Used before surgery since oral therapy is restricted
      • Beneficial for patients suffering from severe vomiting
      • Can be administered to unconscious patients
      • Can be used as targeted drug delivery system
      • – Localized action with reduced systemic distribution
      • Get to site of action with lower dose reducing systemic toxicity
      • Highly beneficial in haemorrhoids or vaginal infections
      • Prolonged drug action achieved
    • Over parenteral drug administration:
      • Self medication
      • No systemic side effects
      • No pain or site of action related issues
    • Over Vaginal Tablets:
      • Suppositories dissolves faster
      • Total bioavailability achieved
      • No residue remains like tablet
      • No need of applicator
      • Non staining
      • Non itching
    • DISADVANTAGES OF SUPPOSITORIES/PESSARIES:
      • Mucosal irritation
      • Patient compliance
      • Erratic and undesired absorption
      • – Placement too high into rectum may lead to first pass metabolism
      • – Installation may trigger defecation reaction
      • GI state affects absorption:
      • – Diarrhea& disease states affect absorption

By Dr. Vibha Kamath

 

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